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Quick Details

  • Type: Glutathione Reduced (GSH)
  • Form: Powder
  • Part: Other
  • Extraction Type: Solvent Extraction
  • Packaging: Drum
  • Place of Origin: Shaanxi, China (Mainland)
  • Grade: Top Grade
  • Brand Name: JT
  • Model Number: Natural Extract

Packaging & Delivery

Packaging Details Packaging Details :Inner double plastic bags--25kg/Fiber drum (35*35*53cm, GW: 28kg, NW: 25kg, 0.06CBM);
Inner double plastic bags--5kg/Aluminum foil bag (GW: 6.5kg, NW: 5kg);
Inner double plastic bags--1kg/Aluminum foil bag (GW: 1.5kg, NW: 1kg).
Delivery Time 3 days after payment received

High quality Natural Glutathione Reduced (GSH) 99%

 

OHI Quality Control


1.100% Nature and competitive prices

2. GMP factory, Steady Supply
3.GMO free, ISO. Kosher & HALAL certified

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Specifications

 

1. 100% Natural Glutathione Reduced (GSH)
2.99%
3best -selling product for skin whitening
4 good at price
5.manufacturer

 

Glutathione(GSH)

1. English Name :  Glutathione Reduced (GSH) 

2.CAS No.:70-18-8

 

3. Type : Herbal Extract

 

4.  Form : Powder

 

5. Specification :  99%

 

6. Appearance :  White  Powder

 

7. Test Method : HPLC 

Introduction

What is GSH?

 

Glutathione (GSH) is an important antioxidant in plants, animals, fungi and some bacteria and archaea, preventing damage to important cellular components caused by reactive oxygen species such as free radicals and peroxides.It is a tripeptidewith a gamma peptide linkage between the carboxyl group of the glutamate side-chain and the amine group of cysteine (which is attached by normal peptide linkage to a glycine).

 

Thiol groups are reducing agents, existing at a concentration of approximately 5 mM in animal cells. Glutathione reducesdisulfide bonds formed within cytoplasmic proteins to cysteines by serving as an electron donor. In the process, glutathione is converted to its oxidized form, glutathione disulfide (GSSG), also called L-(–)-glutathione.

 

Once oxidized, glutathione can be reduced back by glutathione reductase, using NADPH as an electron donor. The ratio of reduced glutathione to oxidized glutathione within cells is often used as a measure of cellular toxicity

 

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High quality Natural Glutathione Reduced (GSH) 99%

 

Functions

 

Glutathione exists in both reduced (GSH) and oxidized (GSSG) states. In the reduced state, the thiol group of cysteine is able to donate a reducing equivalent (H++ e) to other unstable molecules, such as reactive oxygen species. In donating an electron, glutathione itself becomes reactive, but readily reacts with another reactive glutathione to form glutathione disulfide (GSSG). Such a reaction is probable due to the relatively high concentration of glutathione in cells (up to 5 mM in the liver).

 

GSH can be regenerated from GSSG by the enzyme glutathione reductase (GSR): NADPH reduces FAD present in GSR to produce a transient FADH-anion. This anion then quickly breaks a disulfide bond (Cys58 - Cys63) and leads to Cys63's nucleophilically attacking the nearest sulfide unit in the GSSG molecule (promoted by His467), which creates a mixed disulfide bond (GS-Cys58) and a GS-anion. His467 of GSR then protonates the GS-anion to form the first GSH. Next, Cys63 nucleophilically attacks the sulfide of Cys58, releasing a GS-anion, which, in turn, picks up a solvent proton and is released from the enzyme, thereby creating the second GSH. So, for every GSSG and NADPH, two reduced GSH molecules are gained, which can again act as antioxidants scavenging reactive oxygen species in the cell.

 

In healthy cells and tissue, more than 90% of the total glutathione pool is in the reduced form (GSH) and less than 10% exists in the disulfide form (GSSG). An increased GSSG-to-GSH ratio is considered indicative of oxidative stress.

 

Glutathione has multiple functions:

 

  • It is the major endogenous antioxidant produced by the cells, participating directly in the neutralization of free radicals and reactive oxygen compounds, as well as maintaining exogenous antioxidants such as vitamins C and E in their reduced (active) forms.
  • Regulation of the nitric oxide cycle, which is critical for life but can be problematic if unregulated
  • It is used in metabolic and biochemical reactions such as DNA synthesis and repair, protein synthesis, prostaglandin synthesis, amino acid transport, and enzyme activation. Thus, every system in the body can be affected by the state of the glutathione system, especially the immune system, the nervous system, the gastrointestinal system and the lungs.[citation needed]
  • It has a vital function in iron metabolism. Yeast cells depleted of or containing toxic levels of GSH show an intense iron starvation-like response and impairment of the activity of extra-mitochondrial ISC enzymes, followed by death.
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Packing Detail:  

 

 Inside Packing: Double plastic bag

Outside Packing: foil bag/fibre drum

Standard Packing: 1kg/foil bag or 25kg/fibre drum

 

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Storage Situation: 

 

Stored in a cool&dry well-closed container, keep away from moisture and strong light/heat.  

 

Our advantages:

 

 1.Rich experience.

Our company is a professional production leading factory in China in pharmaceutical area for many 
years,our products have exported to Germany, Spain, UK, USA, Australia, Middle East, and so on 
other country, and we have got very good feedback from our customers, we had Established long 
friendly relations of cooperation.

 

2.Great quality, purity and favourable.
High Purity and Good quality are one of our secret success.

 

3.Safe and fast delivery.
we can delivery 100% safe to USA and European countries without 
any customs issue.


4.good after-sales service.
Tell the package update asap, and will try best solve when customer encountered various problems.

 

 

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